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While the goal is to treat patients before the development of acute liver failure, treatment should still be given to patients who are found to be in active hepatic failure since NAC appears to improve hepatic perfusion and oxygen delivery, to refine mitochondrial energy metabolism, and to facilitate scavenging of reactive oxygen and nitrogen species

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The selective COX-2 inhibitors are a new class of NSAIDs, such as etodolac (186) and indomethacin (187)

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